Learn you an assistive technology (AT) for great good
Accessibility ≠ screen readers! But that said, a screen reader is a freely available AT that offers a great perspective on how some people use the technology we design and build.
Sometimes it's very hard to deal with every possible impairment.
For instance, a high contrast ratio can make content more readable for
most folks with visual impairments, but for individuals with
it can do the opposite.
In this case, try to use open standards that allow users to customize your
design via third-party tooling.